Figure 3.

Overrepresented biological processes assigned according to Gene Ontology (GO) classification in cultured skin fibroblasts from the 1^st (C1), 2^nd (C2) and 3^rd (C3) passages compared with the primary culture (C0). Groups of genes fulfilling the criteria: adjusted p-value < 0.1, method = Benjamini, and minimum number of genes per group = 5, are presented in a graph in which the bubble size indicates the number of genes represented in the corresponding annotation and the condition of these genes in terms of their up- and downregulation. The transparency of the bubbles reflects the p-value (more transparent is closer to the border of p = 0.1).