Table 2.
HDACs with mutations or abnormal copy numbers in hematological malignancies
| Gene mutations | Copy number alteration (CNA) | |||||||
|---|---|---|---|---|---|---|---|---|
| Disease | Gene | Mutation number | Case number with mutation | Percentage (total number) | Cytoband | Type of CNA | Case number with CNA | Percentage (total number) |
| AML | HDAC4 | 2 | 2 | 0.3% (622) | NA | NA | NA | NA |
| HDAC7 | NA | NA | NA | 12q13.11 | DEL (deletion) | 1 | 0.5% (191) | |
| CLL | HDAC4 | 1 | 1 | 0.2% (506) | NA | NA | NA | NA |
| DLBCL | HDAC1 | 1 | 1 | 0.7% (135) | 1p35.2-p35.1 | DEL (deletion) | 1 | 2.1% (48) |
| HDAC4 | 3 | 2 | 1.5% (135) | 2q37.3 | AMP (amplifications) | 1 | 2.1% (48) | |
| HDAC7 | 1 | 1 | 0.7% (135) | 12q13.11 | AMP (amplifications) | 2 | 4.2% (48) | |
| DEL (deletion) | 1 | 2.1% (48) | ||||||
| MM | HDAC7 | 1 | 1 | 0.5% (205) | NA | NA | NA | NA |
| NHL | HDAC7 | 1 | 1 | 7.1% (14) | NA | NA | NA | NA |
Notes: NA Not applicable; All data come from the TCGA database