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. 2020 Jan 6;20:5. doi: 10.1186/s12935-019-1071-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Circ_LARP4 up-regulates its host gene LARP4 after transcription. a, b Subcellular fractionation assay and fluorescence in situ hybridization (FISH) were performed to determine that circ_LARP4 was located in cytoplasm. c The expression and protein level of LARP4 after increasing circ_LARP4 were respectively determined by qRT-PCR analysis and western blot assays. d Luciferase reporter assay was used to test the luciferase activity of LARP4 promoter region. e qRT-PCR analysis and western blot assays were applied to analyze the mRNA and protein expression of LARP4 in different groups. f The proliferation ability of transfected cells was measured via colony formation. g Cell invasion capability in different groups was evaluated via transwell. h Western blot analysis of migration-related proteins was conducted. Results were revealed as the mean ± SD. **P < 0.01