. 2020 Jan 6;20:23. doi: 10.1186/s12885-019-6408-4

Table 3.

Relationship between clinical and pathological features of benign and malignant neoplasms of thyroid expressing NEK1, NEK3, and NEK5.* Analysis for Aperio Scan Scope slide scanner

Clinicopathological features	Nek1 Median*	p-value	Nek3 Median*	p-value	Nek5 Median*	p-value
Gender
Female	172.66	0.4315	188.80	0.2823	181.08	0.3118
Male	171.22	0.4315	192.35	0.2823	181.43	0.3118
Age
≤45 years old	172.29	0.3894	188.80	0.2320	183.84	0.1628
>45 years old	173.15	0.3894	190.63	0.2320	181.08	0.1628
Tumor size
<2cm	172.29	0.4171	189.20	0.8575	180.88	0.0074
2–4cm	169.50		194.40		174.80
>4cm	177.83		185.19		195.24
Extrathyroidal Invasion
Yes	168.85	0.3437	188.41	0.1023	185.88	0.0424
No	174.33	0.3437	193.15	0.1023	180.32	0.0424
Capsulation
Yes	174.98	0.4361	194.87	0.0638	176.06	0.0783
No	174.98	0.4361	183.39	0.0638	186.38	0.0783
Multifocality
Yes	175.46	0.0233	189.25	0.3469	182.97	0.4222
No	170.32	0.0233	193.02	0.3469	181.29	0.4222
Metastasis at diagnosis
Present	175.43	0.3648	193.29	0.2473	189.71	0.0108
Absent	173.77	0.3648	188.85	0.2473	179.76	0.0108
Metastasis at evolution
Present	174.84	0.2053	196.97	<0.0001	178.43	0.0572
Absent	172.21	0.2053	183.39	<0.0001	183.67	0.0572
Lymph node metastasis
Present	179.22	0.0239	194.40	0.3475	184.50	0.0921
Absent	167.63	0.0239	197.23	0.3475	176.05	0.0921
TNM
I	173.81	0.3927	186.34	0.0023	181.56	0.8217
II	168.72		202.86		174.75
III	180.43		189.86		185.22
IV	169.83		193.45		182.01