Table 4.
Plasma concentrations of inflammatory factors and TMAO in subgroups of non-PCOS and PCOS without HA cases
| Control | PCOS-N | |||
|---|---|---|---|---|
| BMI < 24 | BMI ≥ 24 | BMI < 24 | BMI ≥ 24 | |
| IFN-α (pg/ml) | 2.61 (2.01–3.11) | 3.91 (2.75–4.70) | 3.04 (2.78–4.15) | 3.54 (1.88–4.44) |
| IFN-γ (pg/ml) | 2.73 (2.27–3.44) | 5.38 (4.16–6.50)a | 3.97 (3.21–5.14) | 5.10 (4.16–6.48)a |
| TNF-α (pg/ml) | 2.73 (2.27–3.24) | 3.44 (2.51–3.67) | 3.17 (2.32–3.44) | 3.04 (2.78–4.15) |
| MCP-1 (pg/ml) | 118.44 (93.42–231.53) | 157.41 (122.61–211.24) | 149.68 (126.77–196.24) | 167.63 (130.55–223.05) |
| IL-6 (pg/ml) | 3.78 (3.66–9.00) | 3.78 (3.66–6.46) | 3.78 (3.66–7.22) | 5.18 (3.66–15.09) |
| IL-8 (pg/ml) | 10.40 (9.01–16.01) | 11.83 (9.03–15.76) | 9.30 (9.00–12.64) | 11.27 (9.30–18.57) |
| IL-10 (pg/ml) | 6.65 (3.72–7.01) | 5.48 (3.72–7.87) | 5.31 (3.72–7.66) | 4.67 (3.84–8.61) |
| IL-17A (pg/ml) | 1.30 (0.94–1.64) | 1.94 (1.90–2.24)a | 1.90 (1.03–2.01) | 2.25 (1.89–2.82)ac |
| IL-18 (pg/ml) | 255.89 (175.33–351.69) | 354.17 (272.48–431.46) | 209.55 (174.31–272.67) | 405.12 (299.34–546.30)ac |
| IL-33 (pg/ml) | 37.71 (20.57–74.61) | 36.79 (18.86–45.30) | 37.99 (24.70–43.98) | 30.18 (7.36–67.58) |
| Plasma TMAO (μmol/L) | 1.65 (0.75–2.09) | 1.64 (1.15–2.59) | 2.18 (1.77–3.86) | 3.01 (1.59–7.17)a |
Data are presented as median (interquartile range). aP < 0.05 versus control-normal weight participants, bP < 0.05 versus control-obese weight participants, cP < 0.05 versus PCOS-normal weight participants. IFN-α Interferon alpha, IFN-γ Interferon gamma, TNF-α Tumor necrosis factor alpha, MCP-1 Monocyte chemoattractant protein-1, IL-6 Interleukin 6, IL-8 Interleukin 8, IL-10 Interleukin 10, IL-17A Interleukin 17A, IL-18 Interleukin 18, IL-33 Interleukin 33, TMAO Trimethylamine N-oxide