. 2020 Jan 6;20:15. doi: 10.1186/s12879-019-4753-1

Table 2.

Clinical Characteristics of Neutropenia-Related Bacillus cereus Meningitis

Symptoms at Onset
Case	Year	Age	Underlying Diseases	WBC Count at Onset	Fever	Headache	Vomiting	Diarrhea	Abdominal Pain	Neurological Abnormalities	CNS Disease	Treatment	Outcome	Reference
1	1973	63	AML	400^a	+					Coma	Brain abscess	GM, OXA, CBC	Dead	5
2	1981	19	AML	<100	+						Meningitis	GM, PCG	Dead	6
3	1988	67	MDS/AML	100^a	+	+	+				Meningoencephalitis/SAH	GM, LM, PIPC	Dead	7
4	1989	3	ALL	20	+					Lethargy	Brain abscess	CP, VCM, GM, RFP	Alive	8
5	1995	26	AML	20			+			Visual disturbance	Meningoencephalitis/SAH	CAZ	Dead	9
6	1997	64	AML	300	+		+	+			Meningoencephalitis/SAH	PIPC, GM, CPZ, CTX, ABPC	Dead	10
7	1997	20	ALL	0	+		+	+	+	Speech disturbance, Sensory disturbance	Cerebral infarction (basal ganglia)		Dead	11
8	1999	13	ALL	0	+				+		Meningoencephalitis/hydrocephalus		Alive, Severe sequelae	11
9	1999	15	ALL	0		+			+		Meningoencephalitis		Dead	11
10	1999	30	AML	<100	+				+	Delirium, hyperventilation	Necrotic meningoencephalitis	CAZ, AMK	Dead	12
11	1999	43	AML	<100	+	+	+	+	+	Delirium, decerebrate rigidity	Meningoencephalitis	CAZ, AMK → VCM, GM & others	Dead	12
12	1999	14	ALL	<100	+					Delirium, epilepsy, coma	Meningoencephalitis	CAZ, AMK & others	Dead	12
13	2003	16	AA	90	+	+				Nuchal rigidity, epilepsy, consciousness disturbance	Meningoencephalitis	CAZ, IPM/CS	Dead	13
14	2005	19	HD	0	+					Confusion, epilepsy, hemiparesis	Meningoencephalitis	ABPC, AMK, CPFX, TEIC, CLDM	Alive	14
Our	case	54	AML	<100	+	+	+			disorientation, slurred speech, and confusion	Meningoencephalitis/hydrocephalus brain abscess	MEPM, LZD, VCM	Alive

^adenotes the number of neutrophils

Abbreviations: AA Aplastic anemia, ABPC Ampicillin, ALL Acute lymphoblastic leukemia, AMK Amikacin, AML Acute myelogenous leukemia, CAZ ceftazidime, CBC, carbenicillin, CLDM Clindamycin, CNS Central nervous system, CP Chloramphenicol, CPFX Ciprofloxacin, CPZ Cefoperazone, CTX Cefotaxime, GM Gentamicin, HD Hodgkin disease, IPM/CS Imipenem/cilastatin, LM Lincomycin, LZD Linezolid, MDS Myelodysplastic syndrome, MEPM Meropenem, OXA Oxacillin, PCG Penicillin G, PIPC Piperacillin, RFP Rifampin, VCM Vancomycin