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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Diabetologia. 2019 Nov 13;63(1):149–161. doi: 10.1007/s00125-019-05030-5

Fig. 3.

Fig. 3

(a, b) Quantification of PFKFB3 immunoreactivity in (a) beta cells and (b) alpha cells in non-diabetic (n=5), pre-type 1 diabetes (n=1) and type 1 diabetes (n=5) samples. Data are mean ± SEM. **p<0.01, two-tailed unpaired Student’s t test. (c, d) Relationship between the percentage of (c) beta cells and (d) alpha cells positive for PFKFB3 and age for non-diabetic (white circles), pre-type 1 diabetes (triangles) and type 1 diabetes (squares) samples. The proportion of PFKFB3-positive beta cells increased with age in individuals without diabetes (r=0.96, p<0.01) but was not related to age in type 1 diabetes. The proportion of alpha cells positive for PFKFB3 was not related to age in individuals without diabetes (p=0.73) nor in those with type 1 diabetes (p=0.08), analysed by Pearson’s correlation analysis. ND, non-diabetic; T1D, type 1 diabetic