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The 3 major time points for use of NIPT are highlighted in this flowchart in red. NIPT may be done instead of sonography (sono) or first-trimester screening (fTs) (1), after sonography and before/instead of first-trimester screening (2), or after sonography and first-trimester screening (3). In case of abnormal sonography and/or first-trimester screening, invasive prenatal diagnostics is indicated.
