Table 4.

Advantages and disadvantages of doing NIPT at the 3 time points given in Figure 2 are listed

Time point	Advantages	Disadvantages
1	DNA is tested, not only phenotype	• Fetus is not tested genetically longer time for results
2	DNA is tested, not only biochemistry and phenotype	• Not all possible genetic changes are detectable • False-positive and -negative results possible
3	Exclusion of most frequent aberrations in placenta of fetus	• No results due to low amount of placental DNA in 3–5% of cases