FIG 6.
Magnitude and kinetics of humoral responses to acute SHIV.CH505.375H.dCT infection during ART and ATI in RMs. Plasma from infant and adult rhesus macaques was analyzed for the HIV CH505 gp120 IgG response (A), blocking of soluble CD4-gp120 interactions (B), the tier 1 neutralization response against MW965 (C), the neutralization response against the CH505 T/F virus (D), and the ADCC titer against CH505 gp120-coated target cells (E). Red symbols represent infant RMs, and blue symbols represent adult RMs. Each symbol represents an individual macaque. Yellow and gray boxes represent the duration of ART and the duration of ATI in the RMs, respectively. Infants with a plasma VL of <15 copies/ml at 12 wpi are represented with open symbols. P values were calculated using the Wilcoxon signed-rank test. eq., equivalents; Ab, antibody; ID50, 50% infective dose.