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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Bone. 2019 Nov 9;131:115078. doi: 10.1016/j.bone.2019.115078

Figure 4.

Figure 4.

Transcriptome changes in WT and Hypo tibiae following mechanical loading. Venn diagrams show the number of DETs (loaded vs. non-loaded) and percentage of increased (↑; red color: F.C. > 2) or decreased (↓; green color: F.C. < 0.5) transcripts after (A) 1-day or (B) 7-day loading. (C). Enrichment analysis of four selected signaling pathways (ECM-receptor interaction, focal adhesion, PI3K-Akt, and Wnt signaling) following loading in WT and Hypo tibiae (Benjamini p < 0.05 indicates statistical significance). The first three pathways were enriched in both genotypes with high significance level after 7-day loading.