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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Bone. 2019 Nov 9;131:115078. doi: 10.1016/j.bone.2019.115078

Figure 5.

Figure 5.

The effects of perlecan deficiency on transcriptome changes in (A) the 1-day study groups and (B) the 7-day study groups. Venn diagrams show the number of DETs (Hypo vs. WT) and percentage of increased (red) or decreased (green) transcripts in both non-loaded and loaded bones. (C). Significant enrichment was found for ECM-receptor interaction and focal adhesion pathways in the cases of 1-day loaded (HL/WL) and/or 7-day non-loaded (HN/WN) and loaded (HL/WL) comparisons. (D) Suppression of ECM-receptor interaction pathway in Hypo bone following 1-day loading (1D HL/WL) was mainly due to decreased transcripts of ECM molecules. (E) Suppression of Focal adhesion pathway in Hypo bone following 7-day loading (7D HL/WL) was due to both decreased ECM and down-stream MLCK and MLC gene/gene groups. Box color: red ↑(increased transcripts); green ↓(decreased transcripts); white →(no change in transcript levels).