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. 2019 Nov 7;40(1):189–205. doi: 10.1161/ATVBAHA.119.313336

Figure 4.

Figure 4.

Expression of ECM (extracellular matrix) genes in the thoracic aorta. A, A volcano plot of the effect of Il17a deletion (IL-17KO [IL (interleukin)-17A knockout]) comparing WT (wild type) and IL-17KO mouse aorta without any challenge. The blue-shaded area and the red-shaded area indicate the genes with significant (P<0.05) suppression (fold change, <0.5) and induction (fold change, >2), respectively. B, Heat map of the hierarchical clustering analysis for genes with the annotation of extracellular matrix. After log conversion of the signal value, the distance from the median is shown in green, black, and red when lower, intermediate, and higher than those of other samples, respectively, within a given gene. The samples are from WT or IL-17KO mice treated with (H) or without (N) high-salt challenge and with or without β-aminopropionitrile+angiotensin II (B+A) challenge. None of the samples had aortic dissection.