Table 3.
Transcripts differentially expressed in group 4, 2 versus 1 and their fold changes
| Disease activity (group 4 vs 1) | ISTX effect (group 2 vs 1) | |||
|---|---|---|---|---|
|
|
|
|||
| Up-regulated | Down-regulated | Up-regulated | Down-regulated | |
| CCR2 (4.71) | CD83 (5.55) | IL10RA (2.74) | CD45RB (3.88) | DUSP4 (2.96) |
| CD45RB (4.4) | DUSP4 (5.54) | ICAM1 (2.67) | EGR1 (3.1) | LGALS3 (2.44) |
| LAIR (2.53) | NFKBIA (4.97) | ICOSLG (2.52) | IFIT2 (2.44) | NOD2 (2.2) |
| SLAMF6 (2.4) | SOCS3 (4.68) | NFKBIZ (2.42) | LILRB2 (2.3) | GBP5 (2.11) |
| BCL6 (2.34) | CXCR4 (4.51) | PRDM1 (2.36) | LAIR1 (2.25) | PRDM1 (2.05) |
| TGFBI (2.34) | BCL3 (4.37) | CCND3 (2.33) | EBI3 (2.19) | |
| IL7 (2.33) | CD96 (3.66) | CDKN1A (2.23) | EGR2 (2.16) | |
| TLR4 (2.2) | BCL2L11 (3.19) | CCL5 (2.21) | BCL6 (2.16) | |
| HRE (2) | FKBP5 (2.89) | HLA-DRB1 (2.17) | NFIL3 (2.08) | |
| TNFAIP3 (2.89) | TRAF4 (2.16) | HRE (2.08) | ||
| IRF1 (2.83) | GBP5 (2.11) | |||
| CCR7 (2.76) | IL13RA1 (2.07) | |||
| SOCS1 (2.74) | NOD2 (2.05) | |||
Among the 4 lists of differentially regulated genes, only those down-regulated in group 4 compared to group 1 revealed significant functional annotation clusters, shown in Table 4.