Table 4.
KEGG pathways which functional annotation clusters of down-regulated genes in group 4 versus 1 revealed
| KEGG pathway | p-value | Benjamini | Genes |
|---|---|---|---|
| TNF signaling pathway | 5.5E-7 | 4.5E-5 | BCL3, CCL5, NFKBIA, TNFAIP3, ICAM1, NOD2, SOCS3 |
| NOD-like receptor signaling pathway | 6.1E-4 | 1.6E-2 | CCL5, NKFBIA, TNFAIP3, NOD2 |
| Epstein-Barr virus infection | 4.5E-4 | 1.8E-2 | NFKBIA, TNFAIP3, CDKN1A, ICAM1, HLA-DRB1 |
| Influenza | 1.7E-3 | 2.7E-2 | CCL5, NFKBIA, ICAM1, HLA-DRB1, SOCS3 |
| HTLV-1 infection | 6.6E-3 | 6.5E-2 | NFKBIA, CCND3, CDKN1A, ICAM1, HLA-DRB1 |
| Cytokine-cytokine receptor interaction | 5.7E-3 | 6.4E-2 | CCL5, CCR7, CXCR4, IL10RA, IL13RA1 |
| Chemokine signaling pathway | 1.8E-2 | 1.2E-1 | CCL5, CCR7, CXCR4, NFKBIA |
Most of them are associated with proinflammatory cascades, of which down-regulation might suppress disease activity of MG.