Table 1. Nano LC-MS / MS analysis identified in the EVs of P (+) and P (-) from macrophages U937.
| Pellets from infected U937 cells (P(+)) | |||
| PROTEIN | PEPTIDES | MATCH | MAX SCORE |
| SPARC | 9 | 16 | 95,2 |
| Alpha-1 Antitrypsin | 5 | 11 | 65,1 |
| Cathepsin L1 | 5 | 13 | 77,8 |
| Ubiquitin/actin fusion protein | 5 | 10 | 52 |
| Actin | 4 | 4 | 58,3 |
| Poly-Ubiquitin | 3 | 10 | 52 |
| Heat Shock Cognate 70 | 3 | 5 | 58,7 |
| 14-3-3 gamma | 3 | 6 | 70,6 |
| Enolase | 3 | 4 | 77,8 |
| 14-3-3 theta | 3 | 4 | 99,5 |
| Niemann-Pick Disease, Type C2 | 3 | 5 | 60,9 |
| Metalloproteinase Inhibidor | 2 | 4 | 89,7 |
| Fibronectin | 2 | 4 | 66,8 |
| Dipeptidyl-Peptidase 7 | 2 | 1 | 71 |
| PDI | 2 | 2 | 79,7 |
| Alix | 2 | 2 | 85,5 |
| Cysteine protease/legumain | 1 | 1 | 65,5 |
| IL6 | 1 | 1 | 65,1 |
| CD81 | 1 | 2 | 77,4 |
| Neuroserpin/serpin1 | 1 | 2 | 63,8 |
| Clusterin | 1 | 2 | 62,6 |
| Calsyntenin | 1 | 1 | 66,6 |
| Neurosecretory protein vfg prec | 1 | 1 | 67,2 |
| Cathepsyn z | 1 | 2 | 54,1 |
| C3 | 1 | 1 | 60,9 |
| Annexin A2 | 1 | 1 | 56,2 |
| Follistatin-Related Protein 1 Precursor | 1 | 1 | 68,1 |
| Immunoglobulin Heavy Constant gamma 1 | 1 | 4 | 75,1 |
| Aldo-ketoreductase | 1 | 1 | 74 |
| Anexin A1 | 1 | 1 | 50 |
| Alpha-N-Acetylglusaminidase | 1 | 2 | 70,2 |
| Glyceraldehyde-3-Phosphate Dehydro | 1 | 1 | 52,8 |
| Pellets from uninfected U937 cells (P(-)) | |||
| PROTEIN | PEPTIDES | MATCH | MAX SCORE |
| Sparc | 6 | 11 | 95,2 |
| Cathepsin L1 | 5 | 10 | 77,8 |
| Alpha-1 Antitrypsin | 4 | 4 | 63 |
| Polyubiquitin | 2 | 6 | 52 |
| Cysteine protease/legumanin | 2 | 4 | 63,4 |
| Enolase | 1 | 3 | 70,2 |
| Alix | 1 | 1 | 63 |
| Annexin A5 | 1 | 1 | 56,6 |
| Transthyretin | 1 | 1 | 63,8 |
| Serpin1 | 1 | 5 | 60,4 |
| Heparan sulfate | 1 | 1 | 55,4 |
| Cathepsin Z | 1 | 2 | 54,1 |
| Calsyntenin 1, Isoform CRA | 1 | 1 | 66 |
Proteins and number of peptides identified by nano LC-MS / MS analysis of the EVs of uninfected (P (-)) and infected (P (+)) macrophages.