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. 2019 Dec 6;6(12):e00248. doi: 10.14309/crj.0000000000000248

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© 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 2. — Squamous cell carcinoma of the esophagus demonstrating (A) atypical cells with positive staining for cytokeratin 5/6 immunostain; (B) squamous differentiation with increased mitosis (hematoxylin and eosin stain, 10×); (C) positive staining for sign apt to 57 within the same tumor confirms neuroendocrine differentiation; and (D) the neuroendocrine tumor demonstrates atypical cells with hyperchromatic nuclei and increased nuclear/cytoplasmic (hematoxylin and eosin stain, 10×).