Table 5.
Comparison of genetic loci associated with PR interval in Hispanic/Latino populations with results from previous genome-wide association studies in European [13, 16], African [11, 19], and Asian [14, 17, 18] descent populations
| Locus | Index SNP in Hispanics/Latinos |
Previously-Identified Index SNPs |
||
|---|---|---|---|---|
| Index SNP | Population | r2 | ||
| SLC8A1 | rs17026148 | rs17026114 | AS | 0.93 |
| rs17026156 | AS | 0.88 | ||
| SCN5A | rs3922844 | rs3922844 | EU, AA | -- |
| rs7638909 | AS | 0.008 | ||
| rs11708996 | EU | 0.06 | ||
| rs6599222 | AA | 0.0003 | ||
| rs6763048 | AA | 0.05 | ||
| SCN10A | rs6801957 | rs6801957 | EU, AA, AS | -- |
| rs6795970 | EU, AS | 0.79 | ||
| rs6800541 | EU, AS | 0.77 | ||
| rs6798015 | AA | 0.80 | ||
| rs6599257 | AS | 0.57 | ||
| ARHGAP24 | rs13105921 | rs7692808 | EU | 0.93 |
| rs7660702 | EU | 0.74 | ||
| rs11732231 | AA | 0.82 | ||
| CAV1-CAV2 | rs3807989 | rs3807989 | EU | -- |
| rs11773845 | EU, AA, AS | 0.99 | ||
| SOX5 | rs146974314 | rs11047543 | EU | 0.97 |
AA, African-descent population; AS, Asian-descent population; EU, European-descent population; r2, Correlation between previously identified index SNP and index SNP identified in Hispanic/Latino population using Hispanic/Latino linkage disequilibrium pattern; SNP, Single nucleotide polymorphism