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. Author manuscript; available in PMC: 2020 Oct 15.
Published in final edited form as: Biochemistry. 2019 Oct 7;58(41):4224–4235. doi: 10.1021/acs.biochem.9b00673

Figure 1. Biochemical function of igr genes.

Figure 1.

(A) Organization of the igr operon in Mtb from Rv3545c (cyp125) to Rv3540c (ltp2). (B) The chemical reactions catalyzed by the gene products encoded by the igr operon. The substrates are 3-OPC-CoA: 3-oxo-4-pregnene-20-carboxyl-CoA; 3-OPDC-CoA: 3-oxo-4,17-pregnadiene-20-carboxyl-CoA; 17-HOPC-CoA: 17-hydroxy-3-oxo-4-pregnene-20-carboxyl-CoA; AD: androstenedione, and propionyl-CoA.