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. Author manuscript; available in PMC: 2020 Jan 8.
Published in final edited form as: Neuromodulation. 2017 Nov 1;21(3):254–260. doi: 10.1111/ner.12712

Fig. 4.

Fig. 4

Immunohistochemical staining for cisplatin-induced c-fos activation in area postrema (AP) and nucleus tractus solitarii (NTS). A. Location (enclosed by dashed line) of c-fos positive cells in nucleus of the solitary tract (NTS; r, rostral; c, caudal) and area postrema (AP) in rats injected with cisplatin (6 mg/kg, ip). Compared with saline, cisplatin increased c-fos expressions in both AP (3B) and NTS (3C) in rats with sham vagotomy surgery. Electroacupuncture (EA) reduced cisplatin-induced c-fos expressions in AP but not in NTS. Subdiaphragmatic vagotomy reduced c-fos expressions in the AP and NTS in both EA and sham-EA groups. #: p < 0.001 compared to Sham-Vagotomy + Sham-EA.