Table 3.
Correlation of PCSK9 with Clinical Variables by Sex
| Clinical Variable | Females | Males | ||
|---|---|---|---|---|
| Correlation Coefficient | p-value | Correlation Coefficient | p-value | |
| Age (years) | −0.02 | 0.87 | 0.12 | 0.26 |
| Systolic BP (mmHg) | 0.28 | 0.15 | 0.04 | 0.83 |
| Diastolic BP (mmHg) | 0.43 | 0.85 | 0.21 | 0.30 |
| BMI (Kg/m2) | 0.61 | 0.04 | 0.05 | 0.63 |
| Fasting glycaemia (g/L) | 0.61 | 0.82 | 0.53 | 0.21 |
| Glycated hemoglobin (%) | 0.53 | 0.1 | 0.39 | 0.92 |
| Total cholesterol (g/L) | 0.09 | 0.43 | 0.05 | 0.67 |
| HDL cholesterol (g/L) | 0.17 | 0.12 | −0.13 | 0.23 |
| LDL cholesterol (g/L) | 0.06 | 0.56 | −0.03 | 0.77 |
| Triglycerides (g/L) | 0.15 | 0.17 | 0.56 | 0.02 |
| hs-CRP (mg/dL) | 0.51 | 0.39 | 0.17 | 0.09 |
Notes: Boldface type indicates statistical significance where p< 0.05. PCSK9 levels were positively correlated to BMI in females and to triglyceride levels in males.
Abbreviations: BMI, body mass index; BP, blood pressure; FPG, fasting plasma glucose; HbA1c, glycated hemoglobin; HDL, high-density lipoprotein; LDL, low-density lipoprotein; PCSK9, Proprotein convertase subtilisin/kexin type 9; hs-CRP, High sensitive C-reactive protein.