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. 2020 Jan 7;11:52. doi: 10.1038/s41467-019-13950-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Pathways are highlighted in blue. Target Enzymes are highlighted in purple; methylthioadenosine phosphorylase (MTAP) and spermidine/spermine N¹-acetyltransferase (SSAT). Pharmacological agents are highlighted in green and next to their corresponding target; Methylthio-DADMe-Immucillin-A (MTDIA) and N¹,N¹¹-bisethylnorspermine (BENSpm). Poylamine biosynthesis enzymes are highlighted in yellow; ornithine decarboxylase (ODC1), s-adenosylmethionine decarboxylase (AMD1), spermidine synthase (SRM) and spermine synthase (SMS). The acetylated polyamine exporter is highlighted in pink; solute carrier 3 family member 2 (SLC3A2).