Table 1.

Summary of all Patient Tumor Data. Indicated values for each parameter were calculated by subtracting combination treatment (using low dose for tumors 1 and 3, high dose for the remaining tumors) values from vehicle control for each tumor. Polyamine (spermidine + spermine) levels were measured by UPLC and normalized to protein concentration. Cleaved caspase-3 (CC3) and spermidine/spermine N1-acetyltransferase (SSAT) scores were determined based on the estimated percent positive cells multiplied by intensity of staining. The final column indicates the number of tumors that increased or decreased for each parameter over the total number of slides.

Tumor	1	3	4	5	6	7A	7B	8	9	10	12	13	14	15	16	17	18	19	20	Total
Polyamines	−20.9	−66.4	−78.9	−42.5	x	−51.4	x	14.8	−14.5	−4.3	x	x	−4.4	−46.9	x	x	−99.7	x	x	10/11 ↓
CCC	0	9	−5	−9	−2	6	10	2	−1	−3	15	−2	5	2	19	8	−2	13	8	11/19 ↑
SSAT	−15	10	13	5	4	10	16	−6	1	3	10	12	6	12	4	8	11	−4	16	16/19 ↑