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. 2020 Jan 7;11:78. doi: 10.1038/s41467-019-13851-6

Fig. 9. The SPAK inhibitor Closantel exhibits dose-dependent neuroprotective effects.

Fig. 9

a Representative images of TTC-stained coronal sections of mouse brain 24 h post tMCAO. Vehicle (Veh) control (DMSO, 2 ml/kg), Closantel (0.1, 1.0, or 2.5 mg/kg), or WNK463 (2.5 mg/kg body weight) were administered i.p. in divided doses at 3 and 8 h post reperfusion after tMCAO. b, c Quantitative analysis of mean infarct volume and mean % hemispheric swelling of mouse brains 24 h post tMCAO. Data are means ± SEM, male mice, n = 14 (vehicle), 8 (Closantel 0.1), 8 (Closantel 1.0), 5 (Closantel 2.5), and 4 (WNK463 2.5). ***p < 0.001 and **p < 0.01 versus vehicle control, one-way ANOVA.