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. 2020 Jan 7;11:54. doi: 10.1038/s41467-019-13753-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a 3C-qPCR at the KLK locus. Bars above the graph illustrate BglII fragments across the region. The 3C bait fragment is indicated by the yellow bar and interacting fragments are shown by red lines (149.2 kb upstream from bait, 163.8 kb downstream from bait). The pink arrows indicate the direction of CTCF motifs. The dotted arrows demonstrate the loops indicated by the interaction data. Error bars represent standard error (SE). b As in a, utilising upstream interacting fragment from a as bait. Interacting fragments are 143.2 and 313.0 kb downstream from the bait. c As in a, utilising downstream interacting fragment from a as bait. Interacting fragments are 68.9, 169.8 and 313.0 kb upstream from the bait.