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. 2020 Jan 7;11:29. doi: 10.1038/s41467-019-13870-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Plotting the predicted associations with AMD based on the model including XL.HDL.C ( $x$ -axis) against the observed associations with AMD ( $y$ -axis) showing all $n = 148$ genetic variants, where the colour code shows Cook's distance for the genetic variants. This is the highest-ranking model on omission of outlying and influential genetic variants from the analysis. Note rs26134 in the LIPC gene region which has an anomalous direction of association with AMD risk in contrast to all other genetic variants.