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. 2020 Jan 7;11:29. doi: 10.1038/s41467-019-13870-3

Table 2.

Ranking of risk factors for age-related macular degeneration (AMD) according to their marginal inclusion probability (MIP) after exclusion of outlying and influential variants (n=145).

Risk factor Marginal inclusion probability (MIP) Model-averaged causal effect θ^MACE
1 XL.HDL.C 0.7 0.344
2 L.HDL.C 0.229 0.087
3 HDL.D 0.087 0.022
4 XS.VLDL.TG 0.082 −0.019
5 LDL.D 0.074 −0.018
6 IDL.TG 0.066 −0.012
7 XXL.VLDL.TG 0.063 0.018
8 S.VLDL.TG 0.062 −0.014
9 Serum.TG 0.061 −0.014
10 Serum.C 0.054 −0.011

Results are given after excluding genetic variants in the APOE, FUTC, and LIPC regions. θ^MACE is the model-averaged causal effect of a risk factor

HDL.D HDL diameter, IDL.TG triglycerides in IDL, L.HDL.C total cholesterol in large HDL, LDL.D LDL diameter, Serum.C serum total cholesterol, Serum.TG serum total triglycerides, S.VLDL.C total cholesterol in small VLDL, S.VLDL.TG triglycerides in small VLDL, XS.VLDL.TG triglycerides in very small VLDL, XL.HDL.C total cholesterol in very large HDL