Table 3.
Associations of type 1 diabetes and type 2 diabetes GRSs with GAD65 antibody positivity in the subcohort and incident diabetes cases; the EPIC-InterAct study
| Variable | Subcohort | Incident diabetes cases | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | OR | Lower | Upper | I2 (%) | N | OR | Lower | Upper | I2 (%) | |
| Type 1 diabetes GRS (per 1 SD) | 12,779 | 1.24 | 1.03 | 1.50 | 46 | 9777 | 1.97 | 1.72 | 2.26 | 12 |
| Type 2 diabetes GRS (per 1 SD) | 11,054 | 0.97 | 0.85 | 1.12 | 0 | 8228 | 0.85 | 0.76 | 0.96 | 0 |
Associations are estimated from logistic regression, adjusted for age and sex. Models fit within each country; estimates combined across countries using random effects meta-analysis