. 2019 Mar 22;34(1):151–159. doi: 10.1007/s10877-019-00267-2

Table 4.

Effect of transpulmonary pressure-directed PEEP titration on hemodynamics in ARDS (n = 6, $\bar{χ}$ ± S)

	Group	T base	T0	T1	T2	T3	T4
HR (beat/min)	TP	89.83 ± 10.38	115.33 ± 19.95^●	116.50 ± 16.42 ^●	116.00 ± 14.71 ^●	118.17 ± 11.61 ^●	120.67 ± 10.34 ^●
HR (beat/min)	MO	93.33 ± 10.80	110.67 ± 21.50 ^●	114.83 ± 12.77 ^●	120.33 ± 17.52 ^●	124.0 ± 14.91 ^●	127.83 ± 13.09 ^●
MAP (mmHg)	TP	120.33 ± 17.41	107.16 ± 17.92	111.00 ± 11.56	111.17 ± 9.20	105.83 ± 14.02	101.33 ± 14.18^●
MAP (mmHg)	MO	120.17 ± 10.93	106.33 ± 12.27	105.83 ± 25.13	105.17 ± 27.45	98.67 ± 21.10^●	89.17 ± 13.89^●
CVP (mmHg)	TP	5.73 ± 0.65	6.02 ± 0.89	6.33 ± 0.82^▲	6.35 ± 1.21^▲	6.33 ± 1.11^▲	6.50 ± 1.05^▲
CVP (mmHg)	MO	5.83 ± 0.75	6.00 ± 0.63	9.17 ± 0.75^●★	9.17 ± 0.98^●★	9.33 ± 0.81^●★	9.33 ± 0.81^●★
CI (l/min/m²)	TP	4.50 ± 0.29	4.49 ± 0.41	4.28 ± 0.60^▲	4.38 ± 0.38^▲	4.23 ± 0.30^▲	4.42 ± 0.47^▲
CI (l/min/m²)	MO	4.53 ± 0.28	4.40 ± 0.48	3.60 ± 0.42^●★	3.34 ± 0.65^●★	3.61 ± 0.85^●★	3.69 ± 0.69^●★
SVI (ml/m²)	TP	50.99 ± 9.79	39.78 ± 6.55	37.08 ± 5.84 ^▲	38.49 ± 7.59^▲	36.30 ± 6.42^●▲	36.97 ± 6.09^●▲
SVI (ml/m²)	MO	49.05 ± 5.90	40.54 ± 5.31	31.31 ± 3.99^●	28.24 ± 4.02^●★	29.60 ± 3.97^●★	29.20 ± 4.66^●★
SVRI (dyn s m²/cm⁵)	TP	2111.17 ± 155.38	1859.67 ± 174.29	2037.67 ± 273.70	2041.17 ± 561.78	1987.33 ± 710.05	1774.33 ± 888.10
SVRI (dyn s m²/cm⁵)	MO	2079.00 ± 228.29	1856.00 ± 127.58	2233.00 ± 419.28	2392.33 ± 562.29	2108.33 ± 466.10	1789.67 ± 476.69
dPmax (mmHg /s)	TP	773.5 ± 61.15	737.67 ± 111.27	766.83 ± 90.02	707.33 ± 58.39	775.0 ± 127.36	799.17 ± 166.02
dPmax (mmHg /s)	MO	827.50 ± 117.38	760.50 ± 48.12	753.0 ± 47.00	726.67 ± 38.17	733.17 ± 19.66	733.17 ± 25.30
GEDI (ml/m²)	TP	585.50 ± 65.81	630.17 ± 124.58	604.0 ± 121.10	606.50 ± 98.83	602.33 ± 99.82	573.0 ± 89.81
GEDI (ml/m²)	MO	594.33 ± 66.28	613.0 ± 77.32	515.67 ± 66.59	515.83 ± 78.63	518.0 ± 92.61	502.67 ± 72.40
ITBI (ml/m²)	TP	722.83 ± 79.72	774.50 ± 164.09	763.0 ± 146.15	749.5 ± 121.56	748.17 ± 123.16	702.0 ± 110.60
ITBI (ml/m²)	MO	798.17 ± 71.99	743.83 ± 113.64	653.50 ± 104.12	658.50 ± 126.99	659.0 ± 150.65	657.5 ± 106.69
LAC (mmol/l)	TP	1.46 ± 0.23	3.03 ± 0.51^●	2.65 ± 0.45	2.15 ± 0.34	1.83 ± 0.39^★	1.65 ± 0.28^★
	MO	1.53 ± 0.23	2.95 ± 0.40^●	2.57 ± 0.45	2.13 ± 0.48	1.80 ± 0.25^★	1.63 ± 0.18^★
DO2 (ml/min/m₂)	TP	485.57 ± 46.17	321.81 ± 8.29^●	464.74 ± 97.34^★	504.18 ± 119.35^★	506.86 ± 146.13^★	485.46 ± 126.51^★
	MO	473.13 ± 38.90	320.16 ± 16.42^●	505.33 ± 71.89^★	513.05 ± 38.81^★	481.13 ± 59.30^★	537.32 ± 92.19^★
Fluid infusion (ml/kg)	TP	–	–	4.5 ± 0.4	4.4 ± 0.3	4.2 ± 0.4	4.6 ± 0.5
	MO	–	–	5.1 ± 0.5	4.9 ± 0.6	4.9 ± 0.5	5.0 ± 0.6
PVPI	TP	2.48 ± 0.33	5.17 ± 1.43^●	3.77 ± 1.77^★▲	3.88 ± 1.53^★▲	3.65 ± 1.07^★▲	3.52 ± 0.91^★▲
	MO	2.35 ± 0.38	4.65 ± 0.73^●	5.22 ± 0.96^●	4.95 ± 1.09^●	5.22 ± 0.96^●	5.52 ± 0.53^●
EVLWI (ml/kg)	TP	15.65 ± 1.33	27.5 ± 5.05^●	18.00 ± 3.16^★▲	18.67 ± 5.50^★▲	18.17 ± 4.26^★▲	17.67 ± 4.46^★▲
	MO	15.83 ± 1.72	30.33 ± 2.87^●	27.33 ± 3.67^●	27.33 ± 3.67^●	29.00 ± 2.61^●	25.17 ± 3.49^●

^●P < 0.05 as compared with T base; ^★P < 0.05 as compared with T0; ^▲P < 0.05 as compared with MO group at the same time point