Fig. 1.

Impact of the diabetes milieu on RTL in fibroblasts: (a) cells exposed to 5.5 mM or 25 mM D-glucose for up to 28 days. In cells grown in 25 mM D-glucose media, the impact of 7 or 14 days culture in (b) 5 mM GA, (c) 25 μM H₂O₂; (d) GA, H₂O₂ and 100μΜ FF combined for 7 days. Data is mean ± SEM. Students’ t-test *P < 0.05 compared to control of the same cell passage, ^#P < 0.05 vs. 7 days GA, ^†P < 0.05 t-test vs. 7 days H₂O₂