FIG 1.

WT and CARD9 mice are both highly susceptible to the C. neoformans H99 strain. (A to D) C57BL/6 and CARD9-deficient mice were given an intranasal inoculation with C. neoformans strain H99. (A) Mice were observed for 29 days for survival analysis. Survival data are from one experiment using 10 mice per group, and the data was analyzed using the log rank test. (B) Pulmonary fungal burden was determined on day 7 or 14 postinoculation. (C and D) Fungal burden was determined in the brains (C) and spleens (D) of mice on day 14 postinoculation. Fungal burden data show the cumulative results of three experiments using five mice per group per time point. Bars indicate the means ± standard errors of the means (SEM) (error bars). Values that are significantly different (P < 0.05) by an unpaired Student’s t test (two-tailed test) or log rank test compared to the values for CARD9-deficient mice are indicated by an asterisk.