Table 1.
Array-based heritability for FEV1, FVC, and FEV1/FVC.
| FEV1 | FVC | FEV1/FVC | ||||
|---|---|---|---|---|---|---|
| UKB LD scores | hg | (SE) | hg | (SE) | hg | (SE) |
| Overall | 0.163 | (0.006) | 0.175 | (0.007) | 0.128 | (0.006) |
| Never smokers | 0.163 | (0.007) | 0.169 | (0.007) | 0.126 | (0.008) |
| Smokers | 0.159 | (0.007) | 0.172 | (0.009) | 0.129 | (0.008) |
| Overall no MHC | 0.162 | (0.006) | 0.175 | (0.007) | 0.125 | (0.006) |
| 1000G LD scores | ||||||
| Overall | 0.201 | (0.008) | 0.214 | (0.010) | 0.157 | (0.010) |
| Never smokers | 0.209 | (0.010) | 0.215 | (0.011) | 0.159 | (0.011) |
| Smokers | 0.208 | (0.010) | 0.221 | (0.011) | 0.166 | (0.010) |
Estimates were obtained using LD score regression applied to genome-wide summary statistics from the UK Biobank (UKB). Two types of LD scores were used: LD scores estimated using UK Biobank (internal reference population) and pre-computed LD scores based on the 1000 Genomes Phase 3 reference population