Table 5. Sensitivity and specificity at three levels of prostate health index (high sensitivity, best combination, high specificity) for prediction of pT3 disease at pathology, Gleason sum ≥7, and Gleason sum upgrading.
| Prediction | Criterion | Sensitivity | Specificity | Positive predictive value | Negative predictive value |
|---|---|---|---|---|---|
| pT3 disease | ≥30.40 | 100.0 (95.5–100.0) | 35.4 (25.0–47.0) | 61.4 (52.5–69.7) | 100.0 (87.7–100.0) |
| ≥45.55 | 93.8 (86.2–98.0) | 91.1 (82.6–96.4) | 91.6 (83.4–96.5) | 93.5 (85.5–97.7) | |
| ≥71.14 | 45.7 (34.6–57.1) | 100.0 (95.4–100.0) | 100.0 (90.5–100.0) | 64.2 (55.1–72.7) | |
| Gleason sum ≥7 | ≥22.29 | 100.0 (96.2–100.0) | 7.81 (2.6–17.3) | 61.9 (53.8–69.6) | 100.0 (47.8–100.0) |
| ≥45.55 | 85.4 (76.7–91.8) | 98.4 (91.6–100.0) | 98.8 (93.5–100.0) | 81.8 (71.4–89.7) | |
| ≥49.93 | 73.96 (64.0–82.4) | 100.0 (94.4–100.0) | 100.0 (94.9–100.0) | 71.9 (61.4–80.9) | |
| Gleason sum upgrading | ≥30.19 | 100.0 (94.3–100.0) | 23.12 (17.2–36.2) | 37.2 (30.9–49.3) | 100.0 (86.1–100.0) |
| ≥45.92 | 91.2 (72.0–97.5) | 66.3 (53.2–75.8) | 58.1 (46.3–69.1) | 94.2 (84.2–98.1) | |
| ≥211.23 | 6.54 (2.1–17.2) | 100.0 (94.1–100.0) | 100.0 (41.3–100.0) | 70.2 (62.1–78.2) |
Values are presented as % (95% confidence interval).