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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Mol Cancer Ther. 2019 Sep 27;19(1):52–62. doi: 10.1158/1535-7163.MCT-19-0052

Figure 2. Activity of hit compounds in secondary confirmatory assay.

Figure 2.

a. Chemical structure of NCGC001177362, Milciclib and PP-121. b-c. The three compounds were tested at 12-doses in five ovarian cancer (OvCa) cell lines for their inhibitory effect on OvCa cell adhesion/ invasion to the 3D organotypic model (16h). b. The EC50 for each compound in each cell line in adhesion/ invasion assay to 3D organotypic model (16h). c. Representative dose-response curves of Tyk-nu OvCa cell adhesion/ invasion to the 3D organotypic model (16h, mean+/− standard deviation, n=8).