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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Mol Cancer Ther. 2019 Sep 27;19(1):52–62. doi: 10.1158/1535-7163.MCT-19-0052

Figure 3. Activity of hit compounds in secondary in vitro biological assays.

Figure 3.

Secondary in vitro screens (adhesion, invasion and proliferation) were performed. The effect of compounds at 4-doses were tested in three ovarian cancer (OvCa) cell lines. OvCa cell adhesion (2h; a) and proliferation (96h; c) were tested in 384-well plates on the 3D organotypic culture. OvCa cancer invasion (24–48h; b) invasion was tested using a 96-well Boyden chamber lined with collagen type I as ECM and the 3D organotypic culture. Mean+/− standard deviation. **, p<0.01. ***, p<0.001. ****, p<0.0001, n=5–8. DMSO, dimethyl sulfoxide.