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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Virology. 2019 Jul 8;535:179–188. doi: 10.1016/j.virol.2019.07.008

Figure 3. NA inhibition activity is induced in sera from N1 VLP immunized mice.

Figure 3.

NA inhibition (NAI) activity in boost immune sera was determined against different stains of influenza viruses by an enzyme-linked lectin assay. (A) NAI activity against homologous A/Cal (H1N1) virus. (B) NAI activity against heterologous rgH5N1 virus. Dotted lines indicate the concentration inhibiting 50% of NA enzyme activity. (C) NAI activity against heterosubtypic A/Phil (H3N2) virus. (D) HAI titers against influenza viruses. Statistical significance was determined by using one-way ANOVA. Data (n=4) are representative of individual animal out of two independent experiments. Error bars indicate the means ± SEM. ***, p<0.001.