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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Virology. 2019 Jul 8;535:179–188. doi: 10.1016/j.virol.2019.07.008

Figure 4. Cross protection induced by mice immunized with N1 VLP.

Figure 4.

The groups of mice with sPR8 or N1 VLP vaccination (n=4 or 8) were challenged with 3× LD50 A/Cal (H1N1), 2.5× LD50 rgH5N1, and 1.5× LD50 A/Phil (H3N2) intranasally at 4 weeks after boost immunization. Body weight changes were monitored for 14 days. (A) Body weight changes against A/Cal (H1N1) virus. (B) Weight changes after rgH5N1 virus infection. (C) Lung viral titers at 7 dpi with rgH5N1. (D) The mortality against A/Phil (H3N2) virus in N1 VLP immunized mice. Data are representative of individual animal out of two independent experiments. Error bars indicate the means ± SEM. ***, p<0.001.