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Molecular target of sorafenib and arsenic trioxide (ATO). A. Sorafenib is known as a multikinase inhibitor which acts through suppressing Ser/ Thr kinase Raf that is known to have important roles in tumor cell signaling and proliferation and B. ATO as a single agent, targets various cellular functions through affecting multiple molecular factors. ATO activates both autophagy and apoptosis.
