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. 2019 Apr 1;12(4):1272–1283.

Figure 1.

Figure 1

LncRNA SNHG12 was up-regulated in the serum of prostate cancer (PCa) patients and correlated to the poor prognosis of PCa patients. A: qPCR showed the expression of SNHG12 in the serum of PCa patients, BPH patients, and healthy controls. *P < 0.05 compared to healthy controls, and #P < 0.05 compared to BPH patients. B: Survival analysis revealed the correlation between SNHG12 expression and the poor prognosis of PCa patients. C-H. LncRNA SNHG12 was up-regulated in PCa cells and dysregulation of SNHG12 regulated LNCaP cell viability, apoptosis and autophagy. C: qPCR showed the expression of SNHG12 in four PCa cell lines, including 22RV1, Du145, LNCaP, MDaPCa2b, as well as in a non-malignant cell line RWPE1. D: qPCR showed the expression of SNHG12 in LNCaP cells after transfection with pcDNA-SNHG12, pcDNA3.1, si-SNHG12#1, si-SNHG12#2 and si-NC. E: MTT assay showed LNCaP cell viability in different transfected groups. F: Flow cytometry showed LNCaP cell apoptosis in different transfected groups. G: Western blot showed the expression of apoptosis-related proteins in different transfected groups. H: Western blot showed the expression of autophagy markers in different transfected groups. *P < 0.05, **P < 0.01, and ***P < 0.001 compared to their respective controls.