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Down-regulation of MAC30 inhibited both PI3K/Akt and Wnt/β-catenin signaling pathways. MCF-7 and MDA-MB-231 cells were transfected with si-MAC30 or si-NC, the p-Akt, t-Akt, β-catenin, survivin and cyclin D1 protein expression levels were analyzed by w and western blotting. All data are presented as mean ± SEM, n=6. #P<0.05, ##P<0.01 vs. si-NC.
