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. 2019 May 1;12(5):1589–1598.

Figure 3.

Figure 3

PQ401 induced U2OS cell apoptosis in a dose-dependent manner. Cells were treated with indicated concentrations of PQ401 for 24 h and stained with Annexin-V/PI. A. A representative flow cytometry result of U2OS in negative control cell culture medium. B. With treatment of PQ401 at 5 µM. C. With treatment of PQ401 at 10 µM. D, E. Statistical analysis showed that PQ401 signifcantly increased both early and late apoptosis in U2OS cells at 10 µM. However, with PQ401 treatment at 5 µM for 24 h, there is no signifcant difference in late apoptosis compared with blank control. Each experiment was performed in triplicate. NS = not signifcant, ***P<0.001.