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. 2019 May 1;12(5):1565–1577.

Figure 5.

Figure 5

Ectopic expression of miR-92a affects the invasion and migration of CRC cells by targeting RECK. (A) si-RECK was transfected into the cells, which was verified by Cy3 fluorescently labeled transfection control siRNA. (B, C) qRT-PCR and western blotting analysis showing that RECK mRNA (P=0.037) and protein were markedly reduced after transfection with si-RECK. (D, E) The status of cell invasion and migration was determined by transwell assays and wound healing assays. The suppression of cell invasion (D) and migration (E) by miR-92a inhibitor was largely abrogated by si-RECK. Mean ± SD, P=0.001. Abbreviations: RECK, reversion-inducing cysteine-rich protein with Kazal motifs; NC, negative control; si-RECK, small-interfering (si)-RECK; Inhibitor, miR-92a inhibitor.