Table 1.

Drugs and inhibitors and their respective TCA or TCA-related enzyme targets.

Drug/Inhibitor	Target	Role of Target	Action of Drug to Target	Sample Type	Reference
AG-120 (Ivosidenib)	IDH1	Catalyze conversion of isocitrate to α-ketoglutarate	inhibit	Clinical trial: glioma, adcanced hematologic malignancy	[87,88]
AG-221	IDH2	Catalyze conversion of isocitrate to α-ketoglutarate	inhibit	Clinical trial: acute myeloid leukemia and myelodysplastic syndrome patients	[86]
Novartis-530	IDH1	Catalyze conversion of isocitrate to α-ketoglutarate	inhibit	Cancer cell lines with somatic IDH1 mutation	[88]
FX 11	LDH-A	Forward and reverse conversion of pyruvate to lactate	inhibit	human lymphoma and pancreatic cancer xenografts	[91]
Dichloroacetate (DCA)	PDK	Phosphorylation and inhibition of PDC	inhibit	Human lung carcinoma cell	[95,96]