Table 2.
miRNAs and their respective TCA or TCA-related enzyme targets.
| miRNA Name | Target | Role of Target | Action of miRNA to Target | Sample Type | Reference |
|---|---|---|---|---|---|
| miR-26a | PDHX | Catalyzes conversion of pyruvate to acetyl coA | inhibit | Colorectal cancer cell lines | [110] |
| miR-146b-5p | PDHB | Conversion of glucose-derived pyruvate to acetyl coA | inhibit | Human colorectal cancer tissue samples, colorectal cancer cell lines | [111] |
| miR-370 | PDHB | Conversion of glucose-derived pyruvate to acetyl coA | inhibit | Human melanoma tissue samples, human melanoma cell line | [112] |
| miR-137 | ASCT2 | Transport of glutamine | inhibit | Human neuroblastoma cell line | [107] |
| miR-183 | IDH2 | Catalyze conversion of isocitrate to α-ketoglutarate | inhibit | Glioblastoma cell lines | [108] |
| miR-181a | IDH1 | Catalyze conversion of isocitrate to α-ketoglutarate | inhibit | Tail-tip fibroblast, mouse embryonic fibroblast | [109] |
| Human lung cancer cell line, human colon cancer cell line, human cervical cancer cell line | [110] | ||||
| Mouse T-cells | [111] |