Table 1.
Descriptive statistics for cohort and stratified by treatment group.
| All Patients N = 434 |
PAP N = 325 |
Control N = 109 |
p-Value | |
|---|---|---|---|---|
| Age, years | 51.9 ± 13.4 | 53.0 ± 13.0 | 48.9 ± 14.0 | 0.008 |
| Female | 219 (50.5%) | 154 (47.4%) | 65 (59.6%) | 0.035 |
| Caucasian | 337 (77.6%) | 258 (79.4%) | 79 (72.5%) | 0.087 |
| Married | 242 (55.8%) | 190 (58.5%) | 52 (47.7%) | 0.170 |
| Median income (×$1000) | 53.3 ± 17.5 | 53.9 ± 17.6 | 51.6 ± 17.3 | 0.244 |
| Smoking status | ||||
| Current | 48 (11.1%) | 34 (10.5%) | 14 (12.8%) | 0.473 |
| Former | 142 (32.7%) | 111 (34.2%) | 31 (28.4%) | |
| Never | 193 (44.5%) | 142 (43.7%) | 51 (46.8%) | |
| Missing | 51 (11.8%) | 38 (11.7%) | 13 (11.9%) | |
| Coronary artery disease | 32 (7.4%) | 24 (7.4%) | 8 (7.3%) | 1.000 |
| Cancer | 76 (17.5%) | 55 (16.9%) | 21 (19.3%) | 0.563 |
| Chronic renal failure | 15 (3.5%) | 10 (3.1%) | 5 (4.6%) | 0.544 |
| Depression | 116 (26.7%) | 81 (24.9%) | 35 (32.1%) | 0.169 |
| Diabetes | 98 (22.6%) | 68 (20.9%) | 30 (27.5%) | 0.185 |
| Hypertension | 168 (38.7%) | 124 (38.2%) | 44 (40.4%) | 0.733 |
| Stroke | 15 (3.5%) | 8 (2.5%) | 7 (6.4%) | 0.067 |
| AHI | 20 (9,44) | 22 (11,49) | 13 (8,32) | <0.001 |
| BMI, kg/m2 | 33 (28,38) | 33 (29,38) | 33 (27,39) | 0.389 |
| Neck circumference, cm | 40 (37, 43.25) | 40 (38, 43.5) | 39.5 (36,43) | 0.101 |
| Family history of RLS | 48 (11.1%) | 35 (10.8%) | 13 (11.9%) | 0.726 |
| RLS medications | 202 (46.5%) | 146 (44.9%) | 56 (51.4%) | 0.268 |
| Exacerbating medications | 198 (45.6%) | 146 (44.9%) | 52 (47.7%) | 0.657 |
| Any caffeine consumption | 325 (74.9%) | 252 (77.5%) | 73 (67.0%) | 0.054 |
| Days from baseline to PSG | 23.5 (6,41) | 23 (7,38) | 25 (5,44) | 0.879 |
| Days from PSG to follow-up | 113 (75,169) | 125 (86,172) | 71 (42,131) | <0.001 |
| Baseline IRLS Score | 16.2 ± 8.3 | 16.3 ± 8.3 | 15.9 ± 8.2 | 0.596 |
| Baseline average sleep time | ||||
| <7 h | 286 (65.9%) | 216 (66.5%) | 70 (64.2%) | 0.615 |
| 7–9 h | 112 (25.8%) | 83 (25.5%) | 29 (26.6%) | |
| >9 h | 27 (6.2%) | 19 (5.8%) | 8 (7.3%) |
Statistics presented as Mean ± SD, Median [P25,P75], or N(column%). PAP: positive airway pressure; RLS: restless leg syndrome; SD: standard deviation; IQR: interquartile range; IRLS: International Restless Leg Syndrome Scale; ESS: Epworth Sleepiness Scale; PHQ-9: Patient Health Questionnaire; PSG: polysomnography.