Table 3.
Association of plasma vitamin C with cancer mortality in 598 kidney transplant recipients.
| Models | Vitamin C (Log2), Continuous (µmol/L) | ||
|---|---|---|---|
| HR a | 95% CI | p Value | |
| Crude | 0.63 | 0.43–0.92 | 0.016 |
| Model 1 | 0.61 | 0.43–0.87 | 0.006 |
| Model 2 | 0.52 | 0.35–0.75 | 0.001 |
| Model 3 | 0.50 | 0.34–0.74 | <0.001 |
| Model 4 | 0.49 | 0.33–0.72 | <0.001 |
| Model 5 | 0.55 | 0.38–0.80 | 0.002 |
| Model 6 | 0.47 | 0.32–0.70 | <0.001 |
Cox proportional hazards regression analyses were performed to assess the association of plasma vitamin C with cancer mortality. Model 1: adjustment for age, sex and smoking status. Model 2: Model 1 + adjustment for estimated Glomerular Filtration Rate, dialysis vintage, time since transplantation and proteinuria. Model 3: Model 2 + adjustment for fruit and vegetable intake. Model 4: Model 3 + adjustment for diabetes mellitus, high-sensitivity C-reactive protein and prior history of cardiovascular disease. Model 5: Model 3 + adjustment for immunosuppressive therapy. Model 6: Model 3 + adjustment for transplantation era. Abbreviations: HR, hazard ratio; CI, confidence interval. a Each model hazard ratio is given per doubling of vitamin C concentration.