Table 4.
Association of plasma vitamin C with cardiovascular mortality in 598 kidney transplant recipients.
| Models | Vitamin C (Log2), Continuous (µmol/L) | ||
|---|---|---|---|
| HR | 95% CI | p Value | |
| Crude | 0.97 | 0.70–1.33 | 0.83 |
| Model 1 | 0.97 | 0.71–1.33 | 0.86 |
| Model 2 | 1.04 | 0.75–1.44 | 0.83 |
| Model 3 | 1.16 | 0.83–1.62 | 0.40 |
| Model 4 | 1.31 | 0.92–1.86 | 0.13 |
| Model 5 | 1.21 | 0.86–1.70 | 0.27 |
| Model 6 | 1.15 | 0.82–1.61 | 0.41 |
Cox proportional hazards regression analyses were performed to assess the association of plasma vitamin C with cardiovascular mortality. Model 1: adjustment for age, sex, and smoking status. Model 2: Model 1 + adjustment for estimated Glomerular Filtration Rate, dialysis vintage, time since transplantation and proteinuria. Model 3: Model 2 + adjustment for fruit and vegetable intake. Model 4: Model 3 + adjustment for diabetes mellitus, high-sensitivity C-reactive protein and prior history of cardiovascular disease. Model 5: Model 3 + adjustment for immunosuppressive therapy. Model 6: Model 3 + adjustment for transplantation era. Abbreviations: HR, hazard ratio; CI, confidence interval.