Table 3.
Overrepresented gene ontology (GO) term at p-value < 0.01 for the genes within regions indicated by both XPEHH and FST to be under selection in SJ horses. GO terms are presented for both for biological processes and pathways.
| PANTHER GOs | Genes | Fold Enrichment | Raw p–Value |
|---|---|---|---|
| Slim Biological Process | |||
| Cell differentiation (GO:0030154) | RBL1, DBX1, SRC, NR1I2 | 5.68 | <0.001 |
| Multicellular organism development (GO:0007275) | DBX1, DLGAP4, NAV2, MYL9, KIAA1755, VSTM2L, GSK3B, NR1I2, POPDC2, DPF2 | 3.33 | 0.002 |
| Small GTPase mediated signal transduction (GO:0007264) | ARHGAP40, ARHGAP31, CDC42EP2 | 6.25 | 0.004 |
| Cellular response to lipopolysaccharide (GO:1901700.) | NR1I2, CD80 | 9.25 | 0.005 |
| DNA conformation change (GO:0071103) | CDCA5, TOP1 | 19.6 | 0.005 |
| Regulation of protein complex assembly (GO:0043254) | ARHGAP40 | 13.1 | 0.011 |
| Purine nucleoside triphosphate metabolic process (GO:0009144) | SAMHD1 | >100 | 0.014 |
| Regulation of sister chromatid segregation (GO:0033045) | CDCA5 | >100 | 0.014 |
| Regulation of exit from mitosis (GO:0007096) | CDCA5 | >100 | 0.014 |
| Protein K48-linked ubiquitination (GO:0070936) | SYVN1 | 71.9 | 0.018 |
| Pathways | |||
| De novo pyrimidine deoxyribonucleotide biosynthesis (P02739) | VSTM2L | 37.7 | <0.001 |
| CCKR signaling map (P06959) | GSK3B, SRC | 6.78 | <0.001 |
| DNA replication (P00017) | TOP1 | 17.3 | <0.001 |
| Angiogenesis (P00005) | GSK3B, SRC, NR1I2 | 4.78 | <0.001 |