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. 2019 Dec 3;8(12):2134. doi: 10.3390/jcm8122134

Figure 5.

Figure 5

Methylation status of the TMPRSS4 and SHOX2 promoter in plasma samples from control individuals and NSCLC patients. Early stages: I–II; late stages: III–IV. (A) Significant hypomethylation of the TMPRSS4 promoter was found in plasma from early stages in comparison with control individuals. (B) ROC curve and area under the ROC (AUROC) for TMPRSS4 methylation status in early stages. (C) The same analysis but for late stages. (D). Significant hypermethylation of the SHOX2 promoter was found in plasma only in the case of late stages. (E,F) ROC curves and AUROC for the SHOX2 methylation status in the case of early (E) or late (F) stages. * p < 0.05.