Table 2.
Multivariable Cox proportional hazards analysis of TMPRSS4 protein expression and relapse-free survival (RFS) or overall survival (OS) in the MDA cohort. Dichotomization of TMPRSS4 expression was based on quartiles (considering (the top 25%, Q4) as high). The prognostic value of TMPRSS4 for both RFS and OS in this early stage is independent of other variables. Only variables whose p-value was ≤0.1 were considered.
| MDA Cohort (n = 489) | |||||||
|---|---|---|---|---|---|---|---|
| RFS | OS | ||||||
| HR | 95% CI | p | HR | 95% CI | p | ||
| Age | <65 | 1 | |||||
| ≥65 | 1.83 | (1.35–2.47) | <0.001 | ||||
| Gender | Female | 1 | |||||
| Male | 0.83 | (0.63–1.10) | 0.211 | ||||
| Smoking habits | Never | 1 | 1 | ||||
| Former | 1.66 | (0.88–3.15) | 0.115 | 1.22 | (0.74–2.02) | 0.416 | |
| Current | 1.99 | (1.02–3.87) | 0.041 | 1.62 | (0.96–2.73) | 0.066 | |
| Histology | ADC | 1 | |||||
| SCC | 1.4 | (1.05–1.08) | 0.02 | ||||
| Other | 1.35 | (0.66–2.78) | 0.406 | ||||
| Stage (8th edition) | I | 1 | 1 | ||||
| II | 1.99 | (1.29–3.08) | 0.002 | 2.15 | (1.55–2.97) | <0.001 | |
| III–IV | 2.73 | (1.70–4.37) | <0.001 | 2.68 | (1.92–3.74) | <0.001 | |
| Adjuvant therapy | No | 1 | |||||
| Yes | 0.72 | (0.47–1.09) | 0.122 | ||||
| TMPRSS4 | Low | 1 | 1 | ||||
| High | 1.82 | (1.28–2.60) | 0.001 | 1.44 | (1.07–1.94) | 0.014 | |
RFS: Relapse-free survival; OS: overall survival.