Table 2.
MDA Cohort (n = 489) | |||||||
---|---|---|---|---|---|---|---|
RFS | OS | ||||||
HR | 95% CI | p | HR | 95% CI | p | ||
Age | <65 | 1 | |||||
≥65 | 1.83 | (1.35–2.47) | <0.001 | ||||
Gender | Female | 1 | |||||
Male | 0.83 | (0.63–1.10) | 0.211 | ||||
Smoking habits | Never | 1 | 1 | ||||
Former | 1.66 | (0.88–3.15) | 0.115 | 1.22 | (0.74–2.02) | 0.416 | |
Current | 1.99 | (1.02–3.87) | 0.041 | 1.62 | (0.96–2.73) | 0.066 | |
Histology | ADC | 1 | |||||
SCC | 1.4 | (1.05–1.08) | 0.02 | ||||
Other | 1.35 | (0.66–2.78) | 0.406 | ||||
Stage (8th edition) | I | 1 | 1 | ||||
II | 1.99 | (1.29–3.08) | 0.002 | 2.15 | (1.55–2.97) | <0.001 | |
III–IV | 2.73 | (1.70–4.37) | <0.001 | 2.68 | (1.92–3.74) | <0.001 | |
Adjuvant therapy | No | 1 | |||||
Yes | 0.72 | (0.47–1.09) | 0.122 | ||||
TMPRSS4 | Low | 1 | 1 | ||||
High | 1.82 | (1.28–2.60) | 0.001 | 1.44 | (1.07–1.94) | 0.014 |
RFS: Relapse-free survival; OS: overall survival.